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Open AccessCommunication by Gemma Chaloner 1, Lizeth Lacharme-Lora 2, Amy Wedley 2 and Paul Wigley 2,3,* 1 School of Life Sciences, University of Liverpool, Liverpool L69 3BX, UK 2 IVES, Faculty of Health and Life Sciences, Leahurst Campus, University of Liverpool, Neston CH64 7TE, UK 3 Bristol Veterinary School, Langford Campus, University of Bristol, Bristol BS40 5DU, UK * Author to whom correspondence should be addressed.
Taken together, the data show that whilst B lymphocytes play a role in immune clearance of C. jejuni, it fails to clear the bacterium from the intestinal tract within the lifetime of a commercial broiler chicken, which is typically around six weeks of age5. We show that birds challenged at 21 days of age do not clear infection from their ceca through B lymphocyte-dependent mechanisms by seven weeks of age. We suggest that colonisation starts in the ileum and then spreads to the jejunum and ceca.
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