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Microbial Ecology Genevieve L. Coe, Nicholas V. Pinkham, Arianna I. Celis, Christina Johnson, Jennifer L. DuBois, Seth T. Walk DOI: 10.1128/AEM.02307-20 ABSTRACT Iron is an essential micronutrient for life. In mammals, dietary iron is primarily absorbed in the small intestine. Currently, the impacts of dietary iron on the taxonomic structure and function of the gut microbiome and reciprocal effects on the animal host are not well understood.
Cytotoxic T Lymphocytes (CTLs) are the major effectors of the host cancer immune surveillance. FasL-induced cytotoxicity is one of the two effector mechanisms that CTLs use to kill tumor cells. Fas is the physiological ligand of FasL and its expression and function is often deregulated in cancer cells. Ceramide is a sphingolipid metabolite that mediates Fas function.
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