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Abstract Myeloid/lymphoid neoplasms with PDGFRB rearrangements are rare hematologic malignancies usually associated with eosinophilia and sensitivity to tyrosine kinase inhibitors, whereas atypical presentations remain poorly defined. We report a 60-year-old man with persistent leukocytosis and thrombocytopenia detected during a routine health examination.
Abstract Hepatocellular carcinoma (HCC) progression involves disruption of oncogenic and tumor-suppressive signaling networks. DEPDC7 (DEP domain-containing protein 7), a liver-specific gene associated with intercellular communication, is highly expressed in normal hepatocytes but markedly downregulated in HCC. Here, we investigated the tumor-suppressive mechanisms of DEPDC7 using Huh-7 cells.
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