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Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement Some or all data, models, or code that support the findings of this study are available from the corresponding author upon reasonable request. Author Contributions Dang Khai Tran: Formal analysis; Investigation; Writing – original draft.
1. Introduction Chronic low back pain (CLBP) is a common condition that affects millions of people worldwide. It is defined as pain that persists for more than 3 months in the lower back region, and is one of the leading causes of disability and work absenteeism.[1] Moving cupping is a traditional therapy that has been used for centuries to manage pain and promote relaxation.
Hepatitis B virus X protein (HBx) acts as a multifunctional protein that regulates intracellular signaling pathways during HBV infection. It has mainly been studied in terms of its interaction with cellular proteins. Here, we show that HBx induces membrane permeabilization independently of the mitochondrial permeability transition pore complex. We generated mitochondrial outer membrane-mimic liposomes to observe the direct effects of HBx on membranes.
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