Abstract White matter (WM) degeneration is an important feature of aging and Alzheimer’s disease (AD). Neurite orientation dispersion and density imaging derived from diffusion tensor imaging (NODDI-DTI) is a technique that allows the estimation of neurite density index (NDI) and orientation dispersion index (ODI) in WM from single-shell diffusion tensor imaging. However, these estimates are tensor-derived approximations rather than direct compartment-specific measures.
