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Articles by Giuseppina De Simone
The role of carbonic anhydrases IX and XII in hypoxia-driven tumor adaptation and chemoresistance: an underexplored frontier for novel therapeutic strategies in ovarian cancer
Abstract Human carbonic anhydrases IX and XII (hCA IX/XII) regulate pH homeostasis and may facilitate tumor adaptation, progression, and therapeutic resistance. Although extensively studied in other malignancies, their roles in ovarian cancer (OC) remain insufficiently characterized. This narrative review critically examines their biological functions and therapeutic potential, emphasizing hypoxia and acidosis within the heterogeneous ovarian tumor microenvironment.
Structural and functional insights into the recombinant PR-10 tomato allergen Sola l 4.02
Abstract Sola l 4.02 is a major tomato allergen of the PR-10 family and a Bet v 1 homolog implicated in pollen–food cross-reactivity, yet its molecular properties remain poorly defined. Here, we report the recombinant production and its comprehensive structural and functional characterization. Sequence and structural analysis support a canonical Bet v 1-like fold including the conserved hydrophobic ligand binding site cavity typical of PR-10 proteins.
Cattolici e cultura. De Simone: «Una fonte che spinge a imparare a pensare la vita»
Da diverse settimane “Avvenire” sta sviluppando un dibattito su cattolicesimo e cultura, avviato dagl i interventi di PierAngelo Sequeri e Roberto Righetto e al quale hanno poi partecipato Gabriel, Forte, Petrosino, Ossola, Spadaro, Giaccardi, Lorizio, Massironi, Giovagnoli, Santerini, Cosentino, Zanchi, Possenti, Alici, Ornaghi, Rondoni, Esposito, Sabatini, Cacciari, Nembrini, Gabellini,Vigini, Timossi, Colombo. Ha senso interrogarsi sul rapporto tra cattolici e cultura?
Co-vulnerabilities of inhibiting carbonic anhydrase IX in ferroptosis-mediated tumor cell death
1 Introduction Hypoxia is an important feature of the tumour microenvironment (TME) of solid cancers and its presence is associated with poor patient prognosis and resistance to anti-cancer therapies (Nakazawa et al., 2016; Gillies et al., 2018). Hypoxia is also known to provide an environmental niche for cancer stem cells and to promote invasion and metastasis (Jain, 2014).
Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding
G. De Simone, A. Angeli, M. Bozdag, C. Supuran, J. Winum, S. M. Monti and V. ALTERIO, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC05755A If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
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