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Articles by Go Ito
220 MULTI-LINEAGE RECRUITMENT TO THE REVIVAL STEM CELL STATE ESTABLISHES RESILIENCE PROGRAMS AND SAFEGUARDS INTESTINAL REGENERATION
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IL-22 induces Paneth cell metaplasia in the colonic epithelium of ulcerative colitis, promoting wound healing via REG3A
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Abstract Paneth cell metaplasia (PCM) is a phenomenon in which Paneth cells, typically found in the small intestine, appear in the colonic epithelium of patients with ulcerative colitis (UC). Our study demonstrates that the PCM occurrence correlates with disease duration and active inflammation.
By Tomohiro Muto, Go Ito, Hiromune Katsuda, Yui Hiraguri, Satoru Fujii, Kurara Yamamoto, Joana P. Bernardes, Finn Hinrichsen, Hitoshi Uchida, Yasuhiro Nemoto, Mayumi Kinoshita, Eri Oshina, Kouhei Yamamoto, Shuji Hibiya, Sayaka Nagata, Fenja Schuran, Shiro Yui, Penelope Pelczar, Samuel Huber, Stefan Schreiber, Philip Rosenstiel, Mamoru Watanabe, Ryuichi Okamoto
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Nature
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Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience
Abstract Plasticity is a central mechanism underlying the robust regenerative capacity of the intestinal epithelium. Two major forms of plasticity have been described: spatial plasticity, in which differentiated cells revert to crypt base columnar cells (CBCs), and fetal reversion into revival stem cells (revSCs). However, the relationship among these two stem cell populations and differentiated cells remains to be clarified.
Time‐course analysis of cerebral circulation and cardiorespiratory responses to acute central blood volume reduction in healthy young males
1 INTRODUCTION Central blood volume (CBV) reduction challenges circulatory and respiratory systems, particularly during gravitational stress, spaceflight and orthostatic hypotension. Lower-body negative pressure (LBNP) has been widely used to simulate these conditions. Although many studies have investigated the steady-state physiological effects of LBNP, the immediate, dynamic responses that occur during the first moments of CBV reduction remain poorly characterized.
Early Process Development and Scale-Up of a Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Process Res. Dev. 2024, 28, 2 Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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