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Abstract This perspective synthesizes published evidence on Ebola vaccination and outbreak preparedness in Africa. Successful vaccination against Zaire ebolavirus has strengthened vaccine-based outbreak control but may also create a preparedness risk when public expectations exceed species-specific vaccine availability.
Background Ketamine is an antagonist of the N-Methyl-D-aspartate (NMDA) receptor with the effect of inducing aberrant excitatory-inhibitory neurotransmission and oxidative neurotoxicity, which mimic the cognitive impairments found in schizophrenia. This study explored the potential of mangiferin, a strong antioxidant xanthone polyphenol, to normalize neurotransmitter levels and mitigate oxidative and glial changes in rats subjected to ketamine treatment.
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