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Abstract Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of haematological malignancies, but its efficacy remains limited by multiple negative regulatory mechanisms intrinsic to T cells1,2,3,4. Here we perform a high-throughput in vivo CAR-T double-knockout (DKO) CRISPR screen, and identify multiple DKO gene pairs that are both effective and synergistic. The top pair, NR4A1–SOCS3 DKO, has multiple favourable immunological features.
SAN ANTONIO – The No. 9 TCU women's soccer team pulled out a hard-fought 1-0 win over UTSA on Sunday night at Park West Athletics Complex. The two teams were gridlocked until the 81st minute of action until Cameron Patton scored off a Grace Vest cross into the box to uplift TCU past the Roadrunners. THE RUNDOWN The Horned Frogs (2-0) battled against UTSA early, with the Roadrunners tallying a handful of early offensive chances throughout a physical first half.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
