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Articles by Grayson Ford
Stereoselective Chemoenzymatic Cascades for the Synthesis of Densely Functionalized Iminosugars
Introduction Click to copy section linkSection link copied! 1,4-Dicarbonyl compounds are versatile synthetic intermediates for the synthesis of heterocycles and bioactive fragments. (1) 2,3-Disubstituted-1,4-diketones (1) are particularly valuable for generation of highly functionalized heterocycles (Figure 1A,B) including pyrroles, (2,3) thiophenes, (4) pyridazines, (5) pyrrolidines (2 and 3), pyrrolines (4), (6−8) and furans (5).
Stereoselective Chemoenzymatic Cascades for the Synthesis of Densely Functionalized Iminosugars
Introduction Click to copy section linkSection link copied! 1,4-Dicarbonyl compounds are versatile synthetic intermediates for the synthesis of heterocycles and bioactive fragments. (1) 2,3-Disubstituted-1,4-diketones (1) are particularly valuable for generation of highly functionalized heterocycles (Figure 1A,B) including pyrroles, (2,3) thiophenes, (4) pyridazines, (5) pyrrolidines (2 and 3), pyrrolines (4), (6−8) and furans (5).
Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades
Cover Picture Ashley P. Mattey, orcid.org/0000-0002-6564-7150 Manchester Institute of Biotechnology (MIB) &, School of Chemistry, The University of Manchester, 131 Princess Street, Manchester, M1 7DN UK Search for more papers by this author Grayson J.
Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**
Abstract A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep cascades in a controlled and selective way. As biocatalytic cascades get more complex, reactions become unattainable under typical batch conditions. Here a number of continuous flow systems were used to overcome batch incompatibility, thus allowing for successful biocatalytic cascades.
Synthesis of Protected 3-Aminopiperidine and 3-Aminoazepane Derivatives Using Enzyme Cascades
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