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Key Points Question How does the efficacy of an investigational 4-factor prothrombin complex concentrate (4F-PCC) compare with a licensed control 4F-PCC for rapid reversal of vitamin K antagonists (VKAs) before urgent surgery? Findings In this randomized clinical trial that included 208 adults taking VKA, the proportion achieving effective hemostasis at the end of surgery was 94.3% with the investigational 4F-PCC vs 94.2% with the control 4F-PCC, demonstrating hemostatic noninferiority.
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
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