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Articles by Gregory Weiss
Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products
1 Introduction Amidines offer a unique functionality with significant capabilities. Their nitrogen-carbon-nitrogen backbone (Figure 1) provides a positive charge, strong basicity, and effective hydrogen bonding capabilities. For example, both amidine nitrogens can serve as a hydrogen bond acceptor and, depending on the amidine substitution, also as a hydrogen bond donor.
A needed boost for abortion access
Women should be able to get an abortion in the U.S. if they so choose, as a majority of Americans believe. But the right to an abortion and access to safe abortions are different issues. And it’s somewhat shocking to know that Martha’s Vineyard — often looked at as a liberal haven — has been classified as an abortion desert. The closest abortion clinic to the Island has been in Attleboro, which poses a burden — particularly for low-income families and individuals.
Putting the Debate to Rest: Recognizing the Role of Sleep in Cardiovascular Health, with Gregory Weiss, MD
Cardiovascular disease (CVD) remains the leading killer of both men and women across the world. While marquee risk factors such as hypertension, diabetes, and obesity enjoy entire disciplines of medicine there exists a multitude of other factors that contribute to long-term CV risk. Everyone knows how important sleep is. So much so that there are entire industries dedicated to facilitating our nightly quest for rest.
What Brings Cardiovascular Patients to the Hospital? With Gregory Weiss, MD
Managing cardiovascular disease often requires the ability to identify the many pieces contributing to the disease and its outcomes much like a jigsaw puzzle that only reveals a picture when the pieces are properly placed together. Like any good detective, cardiologists continually study the patterns of presentation and admissions to hospitals for cardiovascular events in an attempt to decipher a code that could lead to preventing those admissions.
ACC Guidance on CV Consequences of COVID-19, with Gregory Weiss, MD
Dr. Gregory Weiss, a cardiovascular anesthesiologist, provides perspective into the American College of Cardiology's recently released guidance related to the long-term consequences of COVID-19, which includes information on myocarditis, return to athletics, and more. The impact of the novel coronavirus (COVID-19) pandemic on the world has been unprecedented in modern times.
Predicting Cardiovascular Risk Using Routine Mammograms in PostMenopausal Women
Dr. Gregory Weiss expounds on recent data indicating routine mammography in postmenopausal women could help identify women at increased risk of cardiovascular disease based on breast arterial calcification. Cancer and heart disease are the leading killers of women in the United States.1 Sex-specific cardiovascular disease (CVD) markers have become an area of focus in cardiology.
Looking Ahead: Cardiology in 2022, with Gregory Weiss, MD
Dr. Gregory Weiss provides insight into what he is most excited about in the field of cardiovascular medicine heading into 2022. With every new year come new hopes, resolutions, and hopefully progress toward meeting our goals. The cardiology community is no different. However, while many look to drop a few pounds after the holidays or put a little money aside for the future our wish lists as cardiovascular clinicians are often lengthier and loftier by comparison.
The Latest Fashion: Wearables in Cardiology
Dr. Gregory Weiss discusses the topic of wearable technology for remote patient monitoring through the lens of a cardiovascular anesthesiologist. Technology is ubiquitous in our lives from our smartphones to advanced artificial intelligence algorithms telling us what we want to buy on social media platforms. Nowhere has technology played a more crucial role in improving human lives than in the healthcare industry.
Making the cut with protease engineering
Summary Proteases cut with enviable precision and regulate diverse molecular events in biology. Such qualities drive a seemingly inexhaustible appetite for proteases with new activities and capabilities. Comprising 25% of the total industrial enzyme market, proteases appear in consumer goods, such as detergents, textile processing, and numerous foods; additionally, proteases include 25 US Food and Drug Administration-approved medicines and various research tools.
Cigarette Smokers Twice as Likely to Die from Cardiovascular Causes
A new study from Northwestern breaks down the risk of cardiovascular mortality associated with smoking among younger patients. Dr. Gregory Weiss breaks down the study and offers further perspective. It is well known that cigarette smoking is strongly associated with early death and both cardiovascular (CV) and respiratory disease. Over the years, increasing awareness and public health initiatives have led to some reductions in smoking at least in certain populations.
Sodium Content in Processed Meat Varies Country to Country
Dr. Gregory Weiss reviews a recent BMJ article detailing sodium content in processed meats and fish in different countries throughout the world and the implications it could have on cardiovascular health at a national level. Cumulative salt intake has long been associated with cardiovascular health.
ESC Releases New Guidance on Cardiovascular Disease Management During COVID-19 Pandemic
Dr. Gregory Weiss offers a breakdown of the recent ESC guidelines for management of cardiovascular disease during the ongoing COVID-19 pandemic, including specific insight into care pathways, treatment, and follow-up. It has been nearly 2 years since the first cases of clinical COVID-19 were identified. Since then, the novel coronavirus has infected tens of millions of people worldwide and led to unprecedented mortality and morbidity.
Gender Disparities in Cardiovascular Care, with Gregory Weiss, MD
Dr. Gregory Weiss describes gender disparities in cardiovascular care and what type of impact a comprehensive STEMI protocol could have on shrinking these gaps. While cardiovascular disease remains the leading cause of death for both men and women worldwide, females with ST-elevation heart attacks receive less guideline-directed medical therapy, and longer door to balloon times when compared to men.1 This is not a new problem.
The Role of Health Systems in Promoting Adherence to Hypertension Treatments
Gregory Weiss, MD, provides perspective on a recent scientific statement from the AHA outlining the role of health systems in promoting optimal adherence to hypertension therapies and helping patients achieve treatment goals. Hypertension represents the bedrock of cardiovascular disease. From this well springs the myriad of conditions cardiologists see in the office and in the hospital.
Troubled Minds, Broken Hearts: The Link Between Mental Health and Heart Failure
Gregory Weiss, MD, reflects on recent data and an AHA statement related to mental health and increased risk of mortality among patients with heart failure with mental health disorders. Links between mental health disorders and organ system disease have long been known. However, a recent study published in Circulation: Heart Failure found that men with heart failure died with greater frequency if they had severe depression, bipolar disorder, or schizophrenia.
ESC Releases Updated Cardiovascular Disease Prevention Guidelines
Gregory Weiss, MD, provides an overview of the updated cardiovascular disease prevention guidelines from the European Society of Cardiology, which were released at ESC Congress 2021.
Influenza Vaccines: Another Jab at Cardiovascular Disease
Gregory Weiss, MD, reviews and offers perspective on a study presented at ESC Congress 2021 examining the association between influenza vaccines and improved outcomes in patients with cardiovascular disease. The influenza (flu) vaccine has been around for a very long time. Even with highly variable efficacy from year to year, the flu vaccine is routinely recommended for everyone prior to the winter months and especially for high-risk patients.
Who Heals the Healers? The State of Burnout in Cardiology, With Gregory Weiss, MD
Dr. Gregory Weiss tackles the topic of physician burnout in cardiology and offers perspective on the most common causes as well as possible methods of intervention to mitigate the impact of burnout. Physician burnout is a real thing. Ever since I started out in medicine I have read about and heard about physicians saying enough is enough and simply leaving the field. The chorus of discontent has become deafening over my 20 years in the game.
No Longer Fiction: Artificial Intelligence and Modern Cardiology
Dr. Gregory Weiss reflects on the history of artificial intelligence in cardiology and offers perspective on its evolving role as artificial intelligence has demonstrated its ability to improve care and clinical decision-making. The American College of Cardiology (ACC) has long been the flagship for advancement in cardiovascular science and care.
What's New in Hypertrophic Cardiomyopathy, With Gregory Weiss, MD
Hypertrophic cardiomyopathy or HCM is one of the most common genetic or congenital cardiac diseases. Affecting as many as 1 in 500 people HCM is characterized by large increases in cardiac mass, in particular, left ventricular mass.1 Such enlargement predisposes seemingly healthy sufferers to sudden death at young ages.
Life After COVID-19? Long COVID Syndrome from the Front Lines, with Gregory Weiss, MD
Dr. Gregory Weiss, a cardiovascular anesthesiologist, offers perspective on the topic of long COVID syndrome and how the prospect of this phenomenon impacts clinical settings. The evolution of a pandemic is difficult to predict. Even with historical references and prior infectious strains, COVID-19 has proven extremely adaptable and persistent in its spread.
Addressing Equity, Inclusion, & Belonging in Cardiology
The second of 5 slideshows in our multipart series, this slideshow examines the scope of work and conclusions from the AHA/ACC task force who addressed diversity, equity, inclusion, and belonging in cardiovascular medicine.
Navigating Relationships with Industry and Conflicts of Interest in Cardiology
The first of 5 slideshows in our 6-part series, this slideshow examines the scope of work and conclusions from the AHA/ACC task force who addressed conflicts of interest and relationships with industry. This article is the second in a series from Practical Cardiology taking a deeper look at professionalism and ethics within cardiology after the release of a report from the American Heart Association/American College of Cardiology Consensus Conference on Professionalism and Ethics.
Your Provider Will See You Now, with Gregory Weiss, MD
Dr. Gregory Weiss weighs in on the ongoing debate over using the term provider to refer to doctors, which has recently been reignited on social media. I have been practicing in healthcare in one capacity or another for over twenty years. My first job in the hospital was moping the floor in the operating room (OR) at an academic medical center. From there I became an anesthesia technician in the same OR.
Psychosocial Stress Linked to Heart Attacks in Men
A study from the ESC Acute CardioVascular Care 2021 Online Congress is providing clinicians with further insight into the effects of psychosocial stress on the cardiovascular health of men. Stress has long been associated with a variety of medical conditions. Theories for this range from an increase in detrimental behaviors like eating, drinking, and smoking to systemic inflammation created by heightened sympathetic nervous system activity.
Gender Disparities in Acute Myocardial Infarction
Dr. Gregory Weiss, a critical care cardiologist, offers perspective on a study examining disparities in the diagnosis and treatment of women who experience acute myocardial infarction. More and more evidence suggests that women are diagnosed and treated differently than men when it comes to acute myocardial infarction (AMI) or heart attack.
Gregory Weiss, MD: Dreaming of a Post-Pandemic World
Gregory Weiss, MD, reflects on his personal experiences, silver linings, and the prospect of the ongoing COVID-19 pandemic coming to an end in the wake of increased vaccine rollout. I get a lot of questions about COVID-19, from patients and other colleagues. We have certainly been through a lot, and it’s not over yet. We are all looking forward to “the end” or a return to “normalcy”, but it is more apparent than ever that we will likely never return to the way it was before, and we shouldn’t.
Cardiology's Top Advances in the 21st Century with Gregory Weiss, MD
Cardiology's Top Advances in the 21st Century with Gregory Weiss, MD Dr. Gregory Weiss reflects on what he believes are the 6 most significant advances to occur in cardiovascular medicine since 2000. His picks included statins, public awareness campaigns, and transcatheter aortic valve replacement. Related Content:
One Year of COVID-19: A Critical Care Cardiologist's Review
One Year of COVID-19: A Critical Care Cardiologist's Review Dr. Gregory Weiss offers his thoughts on the most clinically impactful studies related to COVID-19 and cardiology released in the past year from his perspective as a critical care cardiologist. Related Content:
Awareness is the Greatest Medicine in Fight Against Cardiovascular Disease with Gregory Weiss, MD
Dr. Gregory Weiss, a critical care cardiologist, reflects on the importance of American Heart Month and the biggest remaining shortcomings in the fight against cardiovascular disease. This February marks the 57th consecutive American Heart Month. Instituted in 1964, 9 years after Lyndon B.
What We Know About COVID-19 and the Heart with Gregory Weiss, MD
In his most recent column, Dr. Gregory Weiss provides an overview of what clinicians have learned related to the effects of COVID-19 on the heart. Over the last year, the global spread of the novel coronavirus COVID-19 has wrought havoc on millions of people and strained the healthcare delivery system.
My Experience with the COVID-19 Vaccine with Gregory Weiss, MD
Dr. Gregory Weiss reflects on his experience receiving the Pfizer COVID-19 vaccine and his thoughts on the ongoing rollout process. So, this happened to me back in December. Working daily as I do here in the trenches of healthcare, I generally learn about my external world via text and email.
Practicing Medicine in the Age of Misinformation with Gregory Weiss, MD
While social media and technology have allowed greater sharing of ideas and knowledge, they have also become a major source of misinformation. In this column, Dr. Weiss reflects on practicing during the age of misinformation. About this time last year, the first cases of COVID-19 were cropping up here in the United States. I myself was largely unaware of any potential infectious disease implications for my patients and the greater community.
Gregory Weiss, MD: My Year in COVID-19
Gregory Weiss, MD, a cardiovascular anesthesiologist and critical care physician, reflects on his experiences during 2020 and coping with the additional stress and responsibilities that accompany the COVID-19 pandemic. There is no doubt that we are living in unprecedented times. Yes, there have been pandemics in the past, even worse than the present. What is different this time? The answer is that the world is much smaller now.
Managing Cardiovascular Disease Risk During Menopause
Dr. Gregory Weiss offers perspective on a recent scientific statement from the American Heart Association outlining strategies to best manage risk of cardiovascular disease in women entering menopause. Cardiovascular disease (CVD) remains the leading cause of death in the world.
Guidelines on Quality Measures for Atrial Fibrillation
Dr. Gregory Weiss explores and gives perspective on the latest guidelines from the AHA and ACC outlining quality measures for adults with atrial fibrillation or atrial flutter It is common from time to time for our flagship organizations to issue guidelines and standards of care based on the latest peer-reviewed research.
Chasing the Sweet Spot: Managing Diabetes in the Modern Era
With the prevalence of diabetes continuing to grow, Gregory Weiss, MD, reflects on his experience treating patients with diabetes as a cardiologist and how recent advances have impacted cardiology. Diabetes mellitus is a spectrum of serious lifelong diseases characterized by abnormally elevated blood glucose levels either due to a failure in insulin production or a reduction in the sensitivity of tissues to intrinsic insulin.
Growing Pains: Perspective on Burnout and Changing Expectations in Medicine
Dr. Gregory Weiss details how the expectations of clinicians, and cardiologists specifically, has changed since he began practicing. Everything changes given enough time. Seventeen years ago, I applied and was accepted to medical school. Like most of the other physicians, I have known I started out with a deep desire to help people and improve their quality of life. The truth is that I was honored to have been selected and felt the weight of that responsibility immediately.
Is it Time to Consider Bariatric Surgery for Primary Prevention?
Dr. Gregory Weiss reflects on data related to bariatric surgery and its subsequent impact on cardiovascular health. Obesity may be the most detrimental health problem of the modern era.
Comparing Cost-Effectiveness of Antidiabetic Therapies with Cardiovascular Benefit
Gregory Weiss, MD, examines 4 studies presented at AHA Scientific Sessions 2020 comparing the cost-effectiveness of antidiabetic agents for reducing cardiovascular events. This year clinicians and researchers across all disciplines of medicine have witnessed many firsts. As we navigate a perilous landscape dominated by the global COVID-19 pandemic, we have seen an extraordinary adaptation in the academic community. Science, medicine, and humanity itself must go on.
Face Time: Virtual Conferencing in the COVID-19 Era
A cardiologist offers his perspective on the pros and cons of virtual medical conferences as a result of the ongoing COVID-19 pandemic. The COVID-19 pandemic has fundamentally changed society as a whole. It is clear that this pandemic will alter human behavior and propel the adoption of novel methods for scientific information-sharing among healthcare professionals. From social distancing to widespread mask-wearing, social interactions have already been drastically altered.
Physician's Perspective: Role of Dietary Assessment in Cardiovascular Disease Screening
Check out the slideshow below for a review of a recent scientific statement from the American Heart Association outlining the need for diet assessments as a screening tool for cardiovascular disease.
Wearable Warriors: Digital Health and the COVID-19 Pandemic
Dr. Gregory M. Weiss reflects on the role of wearable technology before, during, and after the COVID-19 pandemic from the perspective of a cardiologist. Technology plays a central role in the lives of people all over the world. Over the last two decades, technology has bridged the continents bringing people together over great distances while at the same time creating new connections between individuals and their own bodies.
Europe needs to take a stand against radicalisation in the Balkan
Saturday, 13 June 2020 This is an opinion article by an external contributor. The views belong to the writer. Following a letter by MEPs to High-Representative and Vice-President of the European Commission on the danger of foreign funding to radical Salafi agenda in the Balkan, it is about time that Europe takes action to stop radicalisation in the Balkan.
Continuous flow biocatalysis
The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals, and materials has grown tremendously over the past ten years. This revolution in chemical manufacturing has resulted from innovations in both new methodology and technology. This field, however, has been predominantly focused on synthetic organic chemistry, and the use of biocatalysts in continuous flow systems is only now becoming popular.
Antithrombin Administration During Intravenous Heparin Anticoagulation in the Intensive Care Unit
Unfractionated heparin (UFH) is a frequently utilized indirect anticoagulant that induces therapeutic effect by enhancing antithrombin (AT)-mediated procoagulant enzyme inhibition. In suspected heparin resistance (HR) during cardiopulmonary bypass, AT activity may be decreased and AT supplementation helps restore UFH responsiveness. The benefit of AT supplementation in HR over longer durations of UFH therapy is unclear.
Gregory William Weiss - Laredo Morning Times: Obituaries
Greg was a 1973 graduate of Cretin High School, St. Paul, MN and 1979 from the University of Minnesota. He then proudly enlisted in the United States Air Force and served with distinction as an Intelligence Analyst stationed around the world including Italy and South Korea. Greg was later commissioned as an officer and served as a Neonatal Nurse in pediatric intensive care units.
Rapid protein immobilization for thin film continuous flow biocatalysis
A versatile enzyme immobilization strategy for thin film continuous flow processing is reported. Here, non-covalent and glutaraldehyde bioconjugation are used to immobilize enzymes on the surfaces of borosilicate reactors. This approach requires only ng of protein per reactor tube, with the stock protein solution readily recycled to sequentially coat >10 reactors.
Scientists make cancer breakthrough by 'reverse boiling' an egg
CC BY-ND WikiCommonsScientists make cancer breakthrough by 'reverse boiling' an egg Health • January 27, 2015 11:55 AMJanuary 27, 2015 11:55 AM FOLLOW STORY FOLLOW STORY CC BY-ND WikiCommons Added January 27, 2015 at 9:39 a.m. OUR SOURCES How 'Unboiling' an Egg Could Make Treating Cancer Cheaper Scientists Crack the Code on How to Un-Boil a Hard-Boiled Egg Scientists Invent A Way To 'Unboil' An Egg Shear-Stress-Mediated Refolding of Proteins from Aggregates and Inclusion Bodies - Yuan - 2015...
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