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Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description bimj70195-sup-0001-SuppMat.zip475.6 KB Additional Tables may be found in the online version of this article at the publisher's website.Supporting File: bimj70195-sup-0001-SuppMat.zip. References , , , et al. 2023.
REFERENCES 1, , . Estimation of clinical trial success rates and related parameters. Biostatistics. 2019; 20(2): 273-286. 2European Medicines Agency. Reflection Paper on Methodological Issues in Confirmatory Clinical Trials Planned with an Adaptive Design. London: EMEA; 2007. 3, , , et al. The future of drug development: advancing clinical trial design. Nat Rev Drug Discov. 2009; 8(12): 949-957. 4, , .
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