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The flow chart outlining our research is illustrated in Fig. S1. We collected RNA-seq, methylation-seq, and clinicopathological data for liver cancer samples from various sources. Specifically, TCGA-LIHC and ICGC-JP were acquired from Xena (https://xenabrowser.net/datapages/), NODE-OEP000321 were downloaded from NODE (https://www.biosino.org/node/), and GSE59729, GSE41666, and GSE144269 were obtained from GEO (https://www.ncbi.nlm.nih.gov/gds).
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