Biologic medications account for the majority of outpatient treatment expenditures for inflammatory bowel disease.1 The US Food and Drug Administration (FDA) approved adalimumab (Humira, AbbVie Inc) for Crohn disease (CD) in 2007 and ulcerative colitis (UC) in 2012 and approved certolizumab (Cimzia, Union Chimique Belge) for CD in 2006. For Medicare beneficiaries, adalimumab and certolizumab are the biologic agents prescribed by the largest number of gastroenterologists.
