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Abstract OSMRβ is a member of the IL-6 cytokine receptor family and plays a critical role in pruritus and immune-mediated skin diseases. Upon inflammatory stimulation, skin immune cells release OSM and IL-31. These cytokines signal through the heterodimeric receptor complexes OSMRβ/gp130 (type II OSM receptor) and OSMRβ/IL-31RA (IL-31 receptor), which are expressed on keratinocytes, fibroblasts, and dorsal root ganglion (DRG) neurons.
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