Shape memory scaffolds as the minimally invasive cell carriers are a promising biomaterial for tissue regeneration. Since cell fate is critical for successful regeneration, the influence of mechanostructural stimuli induced by shape memory on cell fate is worthy to be put emphasis on. In this study, we developed a poly(L-glutamic acid)-based (PLGA-based) shape memory porous scaffold by cross-linking PLGA with poly(ɛ-caprolactone)-diols (PCL-diols) and particle leaching method.