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Abstract Aging induces endothelial cellular senescence and leads to impaired angiogenesis. Epigenetic alterations are hallmark features of cellular senescence, and noncoding RNAs (ncRNAs) play critical roles in epigenetic regulation. However, the specific roles of circular RNAs (circRNAs) in aging endothelial cells (ECs) and impaired angiogenesis remain largely unknown.
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