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Abstract To improve biological interpretation of immune checkpoint inhibitor (ICI) response in esophageal squamous cell carcinoma (ESCC), we developed an E2F1 transcriptional regulation-related framework integrating spatial multi-omics and experimental validation. Single-cell and post-treatment spatial analyses localized E2F1-associated activity predominantly to malignant epithelial states.
Photoactive platinum(IV) complex conjugated to a cancer-cell-targeting cyclic peptide Huayun Shi,a Qian Wang,b V. Venkatesh,a Guokai Feng,b Lawrence S. Young,c Isolda Romero-Canelón,ad Musheng Zengb and Peter J.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
