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Articles by Guowei Su
Computer Science > Artificial Intelligence
Heterogeneous language-model ensembles expand the space of candidate responses, yet they lack a principled criterion for when a newly generated answer should supersede an already supported one. We decouple candidate headroom from replacement authority, rendering the latter as an explicit, auditable object.
N-Sulfated Heparan Sulfate Promotes Reelin Signaling as a Co-receptor
Cite Jump to ExpandCollapse CommunicationDecember 8, 2025 N-Sulfated Heparan Sulfate Promotes Reelin Signaling as a Co-receptor Click to copy article linkArticle link copied! Lin Pan Lin Pan Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States Xuehong Song Xuehong Song Department of Molecular Pharmacology...
Apolipoprotein E Recognizes Alzheimer's Disease Associated 3‐O Sulfation of Heparan Sulfate
Graphical Abstract The interaction of Apolipoprotein E (ApoE) with cell surface Heparan Sulfate (HS) is enhanced by a rare, Alzheimer's Disease linked 3-O-Sulfo group. This binding motif is shared with tau protein, suggesting a mechanism for ApoE/tau interactions in the association of certain ApoE isoforms with AD. Abstract Apolipoprotein E (ApoE)’s ϵ4 alle is the most important genetic risk factor for late onset Alzheimer's Disease (AD).
Frontispiece: Synthesis of a Systematic 64‐Membered Heparan Sulfate Tetrasaccharide Library
Sherif Ramadan Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 USA Chemistry Department, Faculty of Science, Benha University, Benha, Qaliobiya, 13518 Egypt These authors contributed equally to this work. Search for more papers by this author
Synthesis of a Systematic 64‐Membered Heparan Sulfate Tetrasaccharide Library
Conclusion To expedite the biological understanding of HS, structurally diverse HS structures are critically needed. A systematic library of 64 HS tetrasaccharides with the GlcN-GlcA-GlcN-IdoA backbone sequence has been successfully synthesized for the first time.
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