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H. David Humes on Muck Rack

H. David Humes

Michigan
As seen in: Wiley Online Library, PLOS ONE
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Articles by H. David Humes

New opportunity for targeting systemic inflammation in patients with heart failure through leucocyte immunomodulation

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By Bertram Pitt, H. David Humes
| Wiley Online Library Verified
Introduction Despite current therapy of patients hospitalized with acute (AHF) or worsening (WHF) heart failure, both heart failure with a reduced ejection fraction (HFrEF) and a preserved ejection fraction (HFpEF), there remains a relatively high incidence of cardiovascular (CV) mortality and hospitalizations for HF (HHF) at 30 and 90 days post-admission and/or discharge.1 The administration of sodium–glucose cotransporter inhibitors prior to and or shortly after discharge for AHF or WHF is...
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Translation of immunomodulatory therapy to treat chronic heart failure: Preclinical studies to first in human

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By Keith D Aaronson, H. David Humes, Innovative Biotherapies
| PLOS ONE
Experimental design Canine model. Male mongrel dogs weighing between 21 and 29 kg were used in these studies. HF with HFrEF was induced in these animals using well established published procedures [19]. Utilizing sterile techniques and cardiac catheterization, coronary microembolization using polystyrene microspheres (70–102 um in diameter) was accomplished to promote small left ventricular infarcts while the animals were under general anesthesia.
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