Background: In PREVAIL, pts with progressive mCRPC following ADT had significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) on ENZ vs PL (Beer TM et al, N Engl J MED, 2014). In the current study, the efficacy and safety of ENZ vs PL were evaluated in a similar patient population in China, Taiwan, Hong Kong and South Korea. Methods: Pts with asymptomatic/mildly symptomatic progressive mCRPC following ADT were randomised 1:1 to ENZ (160 mg/day) or PL.