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Transcriptomics reveals novel mechanosensitive genes in endothelial tissue response to flow In healthy arteries resistant to atherosclerosis, blood flow is laminar and unidirectional; however, in arterial sites prone to atherosclerosis such as bifurcations, branches, and curvatures (Zarins et al, 1983; Morbiducci et al, 2016), vascular endothelial cells are constantly activated by disturbed blood flow.
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