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Abstract Despite growing evidence affirming the therapeutic efficacy of ustekinumab (UST) in the treatment of Crohn’s disease (CD), optimizing clinical responses to this biologic continued to pose a significant challenge in clinical practice. From October 2020 to September 2024, a retrospective study was conducted on 114 patients with moderately-to-severely active CD who received optimized ustekinumab by 2 initial intravenous doses in three inflammatory bowel disease (IBD) centers.
1 Introduction Constipation is a prevalent clinical symptom significantly impacting patients' daily activities and overall quality of life (Rao et al. 2016). Insufficient dietary fiber intake, decreased physical activity, and cardiovascular diseases can increase the risk of constipation (Ogasawara et al. 2022).
Few-layered mesoporous graphene for high-performanced toluene adsorption and regeneration Benzene series is one type of volatile organic compounds (VOCs) which causes significant health and environmental issues. Adsorption is an energy-efficient technique for VOC treatment.
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