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1 Introduction A mitochondrion is an essential organelle that controls energy conversion and ATP production (Matsumoto et al., 2012). Mitochondrial fission and fusion maintain the mitochondrial morphology, homeostasis, and inheritance via mitochondrial biogenesis and mitophagy (Ma et al., 2020). Mitophagy is crucial for mitochondrial quality control (Dlamini et al., 2021). Dysfunctional mitochondria can generate apoptotic signals to induce cell death (Zhang, 2013).
Radiation Oncology, Apr 2023 This is a preview of a remote PDF: https://ro-journal.biomedcentral.com/counter/pdf/10.1186/s13014-023-02255-y Lee, Tae Hoon, Kim, Hak Jae, Kim, Jin Ho, Kim, Mi-Sook, Jang, Won Il, Kim, Eunji, Kim, Kyung Su. , Radiation Oncology, 2023, pp. 1-12, Volume 18, Issue 1, DOI: 10.1186/s13014-023-02255-y
Despite the increased incidence of sepsis and septic shock, recent studies have consistently shown a decrease in sepsis mortality over time, owing to advances in medical technology [1, 13]. However, the overall in-hospital mortality rate due to sepsis was still quite high at 29.0% in some recent studies in Korea [10, 14]. Similarly, our study showed that the overall in-hospital mortality rate with sepsis was 28.1%, and the mortality rate for sepsis caused by IAI was 23.3%.
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