Highlight • The RECOVERY trial reported that convalescent plasma had no effect on mortality in COVID-19 • A re-analysis of the data using Bayesian methods suggests there is a real possibility of benefit • The probability of any benefit of plasma in seronegative patients in this trial is more than 75% Introduction Convalescent plasma (CP) – blood components from patients recovered from an infection - has been used for more than a century to treat infections, with widespread use in the 1920’s...
