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Abstract Pulmonary fibrosis (PF) is a progressive lung disease characterized by chronic immune dysregulation and excessive extracellular matrix (ECM) remodeling. Neutrophils, traditionally linked to acute inflammation, are increasingly recognized for their role in fibrosis. In this study, we identified a unique subset of neutrophils undergoing reverse transendothelial migration (rTEM) in the lungs of a silicosis mouse model induced by intratracheal SiO₂ instillation.
Conflicts of interest The authors declare that they have no conflicts of interest. Supporting Information Filename Description febs17164-sup-0001-TableS1.pdfPDF document, 112.4 KB Table S1. Primer sequences. References 1, , , , , , , , , et al. (2018) Phosphoinositide 3-kinase gamma inhibition protects from anthracycline cardiotoxicity and reduces tumor growth. Circulation 138, 696–711. 2, , , , , , , , , et al.
Discussion The main histologic type of bladder cancer is UC. About 3/4 of the tumours are non-muscle invasive UC, and 1/4 of the cases are muscle invasive UC.16 The overall 5-year survival rate for invasive bladder cancer is lower compared with others in the urinary system, with limited response to available treatments such as chemotherapy.
Discussion The main histologic type of bladder cancer is UC. About 3/4 of the tumours are non-muscle invasive UC, and 1/4 of the cases are muscle invasive UC.16 The overall 5-year survival rate for invasive bladder cancer is lower compared with others in the urinary system, with limited response to available treatments such as chemotherapy.
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