CONFLICT OF INTEREST STATEMENT Zhiwei Liu is currently employed by Merck & Co Inc. The other authors declare no conflicts of interest. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available because of privacy or ethical restrictions. Deidentified participant data are deposited in the Research Data Deposit public platform (www.researchdata.org.cn), and will be available on request.