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Abstract Despite studies linking metabolism and cancer, our understanding of the metabolite network that drives metastasis remains incomplete. Through a metabolic RNAi-based screen for cell invasion, we identify alpha-aminoadipate (2-AAA), the intermediate metabolite of aminoadipic semialdehyde synthase (AASS) in the saccharopine pathway, as a common pivotal factor in metastasis of human cancers.
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