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Abstract Traditional laser treatments for café-au-lait macules (CALMs) carry risks of crusting and dyspigmentation. The 730‑nm wavelength offers high melanin absorption, potentially enabling lower energy use with enhanced photoacoustic effects. This study introduces a novel large‑spot, low-fluence 730-nm picosecond titanium sapphire laser protocol designed to be minimally disruptive, distinguished by its non-crusting endpoint and monthly treatment interval.
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