Abstract : As an important topological property for a 3D binary image, the Euler number can be computed by finding specific a voxel block with 2 × 2 × 2 voxels, named the voxel pattern, in the image. In this paper, we introduce three strategies for enhancing the efficiency of a voxel-pattern-based Euler number computing algorithm used for 3D binary images. The first strategy is taking advantage of the voxel information acquired during computation to avoid accessing voxels repeatedly.