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Discussion In a cohort of elderly patients with CRC (stage I–III) who underwent curative resection in a tertiary medical centre, we observed that a higher CLR was associated with an increased risk of death, with CLR levels exceeding 2.53 found to confer 1.5 times higher risk of overall mortality. This simple indicator was subsequently validated in both an external CRC cohort and a localised CRC cohort characterised by a higher prevalence of rectal carcinoma.
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