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The international effort to achieve global COVID-19 vaccination goals faces a dilemma. Stakeholders in this space are at odds over how to treat intellectual property (IP) rights now that viable vaccines are on the market but are inaccessible to vulnerable populations in low- and middle-income countries (LMICS). A key aspect of this debate is whether to grant patent waivers for COVID-19 vaccines and therapeutics.
COVID-19 poses unprecedented challenges to a divided nation led by a President who said about our lack of COVID testing: “I don’t take responsibility at all.” Pennsylvania and Philadelphia, like states and communities nationwide, have agonized over whether to open schools given the tradeoff between the health of students and teachers, and the educational and social benefits of in person classes.
As 2020 approaches, the crowded field of candidates and onlookers are proposing all manner of economic plans designed to increase productivity, encourage competition, decrease wealth disparity, and promote social good. While all may be well-intended, they also have inevitably ignited firestorms of opposing positions accompanied by name calling and denials.
Generation of ATP via oxidative phosphorylation is an essential metabolic function for Mycobaterium tuberculosis (Mtb) regardless of the growth environment. The type II NADH dehydrogenase (Ndh-2) is the conduit for electrons into the pathway, and is absent in the mammalian genome, making it a potential drug target. Herein, we report the identification of two types of small molecules as selective inhibitors for Ndh-2 via a multi-component high-throughput screen.
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