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Articles by Hayan Lee
Author Correction: Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Correction to: Nature Cancer https://doi.org/10.1038/s43018-024-00831-z, published online 30 October 2024. In the version of this article initially published, the surname of Nasim Bararpour was misspelled (Barapour) and is now amended in the HTML and PDF versions of the article.
Discovery of plastid gene mutations causing albinism in chimeric Cornus cultivars (Cornaceae)
Abstract Chimera plants are becoming popular due to their ornamental and aesthetic appeal. Here, we examined the complete plastid genomes (plastomes) and 45S nuclear ribosomal DNAs (nrDNAs) from green and albino leaf tissues (GLT and ALT) of five Cornus cultivars (Cornus florida ‘Cherokee Daybreak’ and four Cornus kousa cultivars).
Polyclonal origins of human premalignant colorectal lesions - Nature
Abstract Cancer is generally thought to be caused by expansion of a single mutant cell1. However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations2,3. Detecting polyclonal tumor initiation is challenging in patients, as it requires profiling early-stage lesions before clonal sweeps obscure diversity.
Author Correction: Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis - Nature Cancer
Correction to: Nature Cancer https://doi.org/10.1038/s43018-024-00823-z, published online 30 October 2024. In the version of the article initially published, a technique described as “intact Micro-C” should have been called “MNase-digested Intact Hi-C” and has now been corrected throughout the article.
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis - Nature Cancer
Abstract Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. We traced the evolution and malignant transformation of colorectal cancer (CRC) by generating high-resolution chromatin conformation maps of 33 colon samples spanning different stages of early neoplastic growth in persons with familial adenomatous polyposis (FAP).
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis - Nature Cancer
Abstract Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and is an ideal model to study transitions of early precancer states to colorectal cancer (CRC). We performed deep multiomic profiling of 93 samples, including normal mucosa, benign polyps and dysplastic polyps, from six persons with FAP.
Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Abstract Although 3D genome architecture can be essential for gene regulation, the biological implications of long-range chromatin interactions in disease remain elusive. In this study, we traced the early evolution and malignant transformation of colorectal cancer by generating high-resolution chromatin conformation maps of 33 colon samples spanning different stages of early neoplastic growth from polyps of Familial Adenomatous Polyposis (FAP) patients.
The Dormancy Types and Germination Characteristics of the Seeds of Berberis koreana Palibin, an Endemic Species of Korea
1. Introduction Plant propagation methods include various methods such as sowing, stem cutting, tissue cultures, and layering. The sowing method has the following advantages: (1) a large number of plants can be secured at once, (2) it reduces labor, and (3) it does not require a relatively large number of auxiliary facilities, in comparison to those required by a tissue culture facility. (4) In addition to these, there are various other advantages.
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma
Abstract Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ESCC genome.
Piercing the dark matter: bioinformatics of long-range sequencing and mapping
Chaisson, M. J. et al. Resolving the complexity of the human genome using single-molecule sequencing. Nature 517, 608–611 (2015). This is the first major publication describing how PacBio long reads could be used for human genetics, showing that over 20,000 SVs are present in a typical human genome. Rand, A. C. et al. Mapping DNA methylation with high-throughput nanopore sequencing. Nat. Methods 14, 411–413 (2017).
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