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Articles by He Xia
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles
Abstract Lipid nanoparticles (LNPs) have great potential as nucleic acid delivery vehicles; however, they trigger the production of inflammatory cytokines, which limits their medical applications. Developing non-inflammatory LNPs is challenging because the LNP’s ionizable lipid and the process of endosomal disruption are the major sources of LNP toxicity but are also essential for delivering nucleic acids.
Engineering Neural Stem Cells with Micropatches for Improved Therapy of Traumatic Brain Injury
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Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization
Conflict of interest The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Probiotic Pediococcus pentosaceus Li05 Improves Cholestasis through the FXR-SHP and FXR-FGF15 Pathways
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Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice
Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice Gut microbiota is closely related to lipopolysaccharide (LPS)-induced acute lung injury (ALI). As was issued, Akkermansia muciniphila (A. muciniphila) maintained the intestinal barrier function and regulated the balance of reduced glutathione/oxidized glutathione. However, it may be useful as a treatment strategies of LPS-induced lung injury.
Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate
3. Results 3.1. Ketogenic Diet Exacerbated L-Arginine-Induced Acute Pancreatitis and Induced Dysfunction of the Intestinal Barrier To estimate the influence of the ketogenic diet on acute pancreatitis (AP), a long-period ketogenic diet (KD) was followed for 16 weeks, and the acute pancreatitis was induced by intraperitoneal injection of L-arginine (Arg) as the scheme (Figure 1A).
Multifunctional Hydroxyapatite Nanobelt Haystacks Integrated Neural Stem Cell Spheroid for Rapid Spinal Cord Injury Repair
Abstract Due to the unwarranted lifespan and differentiation, applying neural stem cells (NSCs) in spinal cord injury (SCI) remains challenging. In this study, 3D bioactive hydroxyapatite (HAp) nanobelt haystack-mouse NSC (mNSC) hybrid spheroids are customized in which the specific nanobelt haystack framework provided the structural function of hypoxia alleviation in the spherical core and biological process of neural differentiation promotion.
Mesoporous Silica Promotes Osteogenesis of Human Adipose-Derived Stem Cells Identified by a High-Throughput Microfluidic Chip Assay
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