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Abstract Undifferentiated carcinoma of the pancreas with rhabdoid features is a rare and lethal variant, comprising less than one percent of all pancreatic cancer cases. Here we present a single patient case with in-depth molecular characterization, including whole exome DNA sequencing and GeoMx/CosMx spatial transcriptome profiling.
In pancreatic ductal adenocarcinoma (PDAC), early onset of hypoxia triggers remodeling of the extracellular matrix, epithelial-to-mesenchymal transition, increased cell survival, the formation of cancer stem cells, and drug resistance. Hypoxia in PDAC is also associated with the development of collagen-rich, fibrous extracellular stroma (desmoplasia), resulting in severely impaired drug penetration.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
