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Heidi C. E

As seen in: Nature, Frontiers
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Articles by Heidi C. E

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses

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By Signalling Programme, Imaging Facility, Bioinformatics Facility, Heidi C. E
| Frontiers
Introduction Neutrophils are leukocytes of the innate immune system that provide the first line of defence against bacterial and fungal infections, as well as fulfilling important roles in inflammation. They are recruited from the blood stream into infected tissues where they phagocytose, degranulate, and generate reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) to destroy invaded microorganisms (1–3).
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Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis

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By Anna-Karin E, Heidi C. E
| Frontiers
Polly A. Machin1, Anna-Karin E. Johnsson1, Ellie J. Massey1, Chiara Pantarelli1, Hanneke Okkenhaug1, Anne Segonds-Pichon1, Simon Walker1, Angeliki Malliri2, Yoshinori Fukui3 and Heidi C. Welch1* 1Babraham Institute (BBSRC), United Kingdom 2Cancer Research UK Manchester Institute, The University of Manchester, United Kingdom 3Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Japan The final, formatted version of the article will be published soon.
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Behavioural immune landscapes of inflammation - Nature

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By Jackson Liang Yao, Del Valle, Alfonso Serrano Verified, Heidi C. E
| Nature Verified
Abstract Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing cellular landscapes of healthy and diseased tissues1,2. These approaches, however, do not describe dynamic scenarios in which cells continuously change their biochemical properties and downstream ‘behavioural’ outputs3,4,5.
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