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Articles by Heiko Tzschätzsch
Automated segmentation and quantification of histological liver features for MASH/MASLD scoring
Abstract The increasing global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) including metabolic dysfunction-associated steatohepatitis (MASH) creates an urgent need for objective histopathological assessment. Conventional histological approaches are time-consuming and subjective. Therefore, we propose a fully automated, deep-learning-based pipeline for the segmentation and characterisation of histological liver features of MASH/MASLD.
Ex-vivo magnetic resonance elastography detects inflammation-associated biomechanical changes in a mouse model of Salmonella -induced colitis
Abstract Inflammation alters the mechanical properties of soft tissues, yet the biomechanics of the inflamed intestine remain poorly characterized. Using magnetic resonance elastography (MRE), we characterized colonic biomechanical properties in a murine colitis model. CBA/J mice infected with Salmonella Typhimurium were sacrificed at days 5, 16 and 30 post infection alongside uninfected controls.
Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
Priority Report Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke and Ingolf Sack DOI: 10.1158/0008-5472.CAN-19-2150 Published November 2019 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
Priority Report Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke and Ingolf Sack DOI: 10.1158/0008-5472.CAN-19-2150 Abstract Patients with increased liver stiffness have a higher risk of developing cancer, however, the role of fluid–solid tissue interactions and their contribution to liver tumor malignancy remains elusive.
Tomoelastography distinguishes non-invasively between benign and malignant liver lesions
Priority Report Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan Rodrigo Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Josef A Käs, Jürgen Braun, Timm Denecke and Ingolf Sack DOI: 10.1158/0008-5472.CAN-19-2150 Abstract Patients with increased liver stiffness have a higher risk of developing cancer; however, the role of fluid-solid tissue interactions and their contribution to liver tumor malignancy remains elusive.
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