Introduction Acute coronary syndrome (ACS) patients are at high risk of developing long-term heart failure (HF) and premature mortality.1 In the past decades, improved treatment strategies in myocardial infarction (MI) patients have led to a decreased incidence of recurrent MI and cardiovascular (CV) death.2 However, the rate of HF development during the first year after an ST-elevation myocardial infarction (STEMI) has only slightly improved, from 7.1% to 6.2%.2 Defining novel disease...