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Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description hel70098-sup-0001-Supinfo.docxWord 2007 document , 5.8 MB Figure S1: QQ plot of the meta-analysis of genome-wide association studies.
Key Points Question Is genetic susceptibility for gastric cancer associated with the outcomes of its primary prevention strategies? Findings In this cohort study of more than 100 000 Chinese adults, a polygenic risk score associated with the risk of gastric cancer was derived. Helicobacter pylori treatment was associated with reduced gastric cancer risk for individuals with a high genetic risk during long-term follow-up but not for those with low genetic risk.
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