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Articles by Henry Ko
Nanobody-Targeted Conditional Antimicrobial Therapeutics
Introduction Click to copy section linkSection link copied! Most investigational therapeutics fail in clinical trials because they lack efficacy or show unacceptable toxicity. (1−4) Therapeutics with improved properties are identified through modification of their molecular properties and screening. (5,6) Formulation of therapeutics with various drug delivery systems (e.g., encapsulation into or conjugation to nanocarriers or biomacromolecules) may also lead to improvement in efficacy.
Nanobody-targeted conditional antimicrobial therapeutics
Abstract Conditional therapeutics that rely on disease microenvironment-specific triggers for activation are a promising strategy to improve therapeutic cargos. Among the investigated triggers, protease activity is used most often, because of its dysregulation in several diseases. How to optimally fine-tune protease activation for different therapeutic cargos remains a challenge.
CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics - Nature Nanotechnology
Abstract Synthetic biomarkers, bioengineered sensors that generate molecular reporters in diseased microenvironments, represent an emerging paradigm in precision diagnostics. Despite the utility of DNA barcodes as a multiplexing tool, their susceptibility to nucleases in vivo has limited their utility. Here we exploit chemically stabilized nucleic acids to multiplex synthetic biomarkers and produce diagnostic signals in biofluids that can be ‘read out’ via CRISPR nucleases.
Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids
Download Hi-Res ImageDownload to MS-PowerPointCite This:Mol. Pharmaceutics 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Ester J. Kwon*, Henry Ko Henry Ko Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States , and Sangeeta N. Bhatia* Sangeeta N.
A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army
Introduction In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel. Methods Searches for studies examining biotechnological and pharmacological products in Army populations were conducted in December 2015. Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and PsycINFO were searched without date or language restrictions.
A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army
Introduction In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel. Methods Searches for studies examining biotechnological and pharmacological products in Army populations were conducted in December 2015. Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and PsycINFO were searched without date or language restrictions.
Workplace bullying: A problem that’s not going away
Is the U.S. workplace simply getting meaner? A new study shows an alarming jump in the rate of employees being bullied by their co-workers, supervisors — and even customers. The research, from CareerBuilder and Harris Interactive, says 35% of workers said they have felt bullied at work — up from 27% last year. Of that number, 16% reported they suffered health-related problems as a result of the workplace bullying — and 17% decided to quit their jobs because of it.
In science communication, why does the idea of a public deficit always return? How do the shifting information flows in healthcare affect the deficit model of science communication?
The healthcare field contains a multitude of opportunities for science communication. Given the many stakeholders dancing together in a multidirectional tango of communication, we need to ask how much does the deficit model apply to the health field? History dictates that healthcare professionals are the holders of all knowledge, and the patients and other stakeholders are the ones that need the scientific information communicated to them.
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