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Articles by Himani Sachdeva
Genetic load, eco-evolutionary feedback and extinction in metapopulations
Abstract Habitat fragmentation poses a significant risk to population survival, causing both demographic stochasticity and genetic drift within local populations to increase, thereby increasing genetic load. Higher load causes population numbers to decline, which reduces the efficiency of selection and further increases load, resulting in a positive feedback which may drive entire populations to extinction.
Effect of assortative mating and sexual selection on polygenic barriers to gene flow
Abstract Assortative mating and sexual selection are widespread in nature and can play an important role in speciation, through the buildup and maintenance of reproductive isolation (RI). However, their contribution to genome-wide suppression of gene flow during RI is rarely quantified.
The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow
Abstract We consider how the genetic architecture underlying locally adaptive traits determines the strength of a barrier to gene flow in a mainland-island model. Assuming a general life cycle, we derive an expression for the effective migration rate when local adaptation is due to a polygenic trait under directional selection on the island, allowing for arbitrary fitness and dominance effects across loci.
Genetic load, eco-evolutionary feedback and extinction in a metapopulation
Abstract Fragmented landscapes pose a significant threat to the persistence of species as they are highly susceptible to heightened risk of extinction due to the combined effects of genetic and demographic factors such as genetic drift and demographic stochasticity. This paper explores the intricate interplay between genetic load and extinction risk within metapopulations with a focus on understanding the impact of eco-evolutionary feedback mechanisms.
Polygenic barriers to gene flow: the role of dominance, haploid selection and heterogeneous genetic architectures
Abstract We study the maintenance of polygenic local adaptation and its effects on reproductive isolation in a mainland-island model for populations with a general biphasic life cycle, encompassing haploid and diploid models as special cases.
Limits to selection on standing variation in an asexual population
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Reproductive isolation via polygenic local adaptation in sub-divided populations: Effect of linkage disequilibria and drift
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Abstract This paper considers how polygenic local adaptation and reproductive isolation between hybridizing populations is influenced by linkage disequilibria (LD) between loci, in scenarios where both gene flow and genetic drift counteract selection.
Reproductive isolation via polygenic local adaptation in sub-divided populations: effect of linkage disequilibria and drift
Abstract This paper considers how local adaptation and reproductive isolation between hybridizing populations is influenced by linkage disequilibria (LD) between multiple divergently selected loci in scenarios where both gene flow and genetic drift degrade local adaptation.
Genetic load and extinction in peripheral populations: the roles of migration, drift and demographic stochasticity
New Results Himani Sachdeva, View ORCID ProfileOluwafunmilola O Olusanya, Nick H Barton doi: https://doi.org/10.1101/2021.08.05.455207 Abstract We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers declines with increasing load.
Preparing India for urban acceleration
As the economy advances towards incentivising wealth creation, environmental sustainability and technologically proficiency, urbanisation acceleration is inevitable. An amount of Rs 8,000 crore has also been set apart for incubation of eight new cities. By Himani Sachdeva & Satwik Mishra Never before in history has such a high volume of population shifted from rural to urban locales as is currently happening in India today.
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