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Articles by Hiroki Ota
Graded-modulus tri-layer substrates for stress-relieved direct fabrication of integrated stretchable systems
Abstract Stretchable electronics capable of integrating high-performance components while accommodating large mechanical deformations are increasingly in demand for wearable devices and soft robotics.
Unmyelinated nerve fibers distributed in the human crural fascia of Thiel-embalmed cadavers
Abstract Muscle fascia is implicated to play a role in musculoskeletal pain; however, the distribution of unmyelinated nerve fibers within human fascia remains to be characterized. Conventional formalin fixation of biological tissues for long periods degrades the antigenicity of protein markers, often resulting in loss of nerve fiber immunoreactivity, limiting immunohistochemical analysis.
Phenethyl isothiocyanate activates leptin signaling and decreases food intake
Obesity, a principal risk factor for the development of diabetes mellitus, heart disease, and hypertension, is a growing and serious health problem all over the world. Leptin is a weight-reducing hormone produced by adipose tissue, which decreases food intake via hypothalamic leptin receptors (Ob-Rb) and the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway.
EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contraction
We previously demonstrated that nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) were upregulated after lengthening contraction (LC) in exercised muscle through B2 bradykinin receptor activation and cyclooxygenase (COX)?2 upregulation, respectively, and that these trophic factors sensitized nociceptors resulting in mechanical hyperalgesia (delayed?onset muscle soreness, DOMS). Here we examined the prostaglandin receptor subtype involved in DOMS.
New wristband measures sweat to monitor health risks
Most fitness trackers—even the most sophisticated ones on the market—can’t do much more than count your steps or measure your heart rate. But researchers have developed a device that can do much more: Built into a headband or wristband, it can monitor chemicals in the body’s sweat that may be used to non-invasively assess medical conditions, discern drug abuse, or help coaches and trainers optimize the performance of elite athletes, scientists say.
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