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In previous studies, we showed that optineurin and Htt are associated with inactive Rab11 and others demonstrated that optineurin, named as FIP-2, interacts with Htt12,13. We used association with inactive Rab11 to search for other potential Htt interacting proteins. By mass spectrometry, we identified RhoGEF kalirin from proteins precipitated by inactive GST-Rab11 (data not shown).
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