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Abstract This study investigated the roles and mechanisms of PINK1 activity in neonatal hypoxia-induced seizures with shRNA intervention targeting translocase outer mitochondrial membrane 7 (TOM7), the positive regulator of PINK1 autophosphorylation, or overlapping with the m-AAA protease 1 homolog (OMA1), the negative regulator of PINK1 autophosphorylation.
1 Introduction of febrile seizures 1.1 Definition and symptoms of febrile seizures Febrile seizures (FSs) refer to convulsions induced by a sudden increase in body temperature (>38°C) in the absence of other underlying causes or disorders that induce convulsions, such as central nervous system (CNS) infections, electrolyte abnormalities, withdrawal, trauma, genetic predisposition or known epilepsy (Xixis et al., 2022).
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