Abstract Background: Postoperative delirium (POD) is a common complication in elderly surgical patients that can impede recovery. While remimazolam offers superior hemodynamic stability compared to propofol, its impact on POD incidence remains unclear. This randomized trial aimed to determine whether two induction doses of remimazolam are more effective than propofol in reducing POD and improving hemodynamic stability in older patients undergoing laparoscopic gastrointestinal surgery.