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Articles by Howard R Petty
What Applied Physical Chemistry Can Contribute to Understanding Cancer: Toward the Next Generation of Breakthroughs
Abstract : Living systems, whether healthy or diseased, must obey the laws of chemistry. The purpose of this review is to identify the interpretive limits of cellular biochemistry using, largely, the tools of physical chemistry. We illustrate this approach using two major concepts in cancer: carcinogenicity and cancer recurrences. Cells optimize the chemical performance of enzymes and pathways during cancer recurrences.
Using Machine Vision of Glycolytic Elements to Predict Breast Cancer Recurrences: Design and Implementation
1. Introduction As metabolism is a border between life and death, its importance can hardly be overestimated. Changes in metabolism are also important because they enable specific physiological changes. One broadly important metabolic change is the acquisition of aerobic glycolysis, the catabolism of glucose to lactate in the presence of oxygen (1–3). For example, aerobic glycolysis is associated with cell development and adaptive immunity [1,2].
Study of Breast Cancer Recurrence Features May Lead to New Testing for Risk
Newswise — Article title: Spatial locations of certain enzymes and transporters within pre-invasive ductal epithelial cells predict human breast cancer recurrences Authors: Alexandra M. Kraft and Howard R. Petty From the authors: “In the future, it will be important to increase the number of [breast cancer] patients studied and digital micrographs quantified to insure that the findings can be generalized to all patients and their ducts and to improve the precision of machine learning.
Spatial locations of certain enzymes and transporters within pre-invasive ductal epithelial cells predict human breast cancer recurrences
Research ArticleCall for Papers: Cellular Processes in Tumor Metastasis: Basic Research to Translation Alexandra M. Kraft and Howard R. Petty Abstract Some patients treated for ductal carcinoma in situ (DCIS) of the breast will experience cancer recurrences, whereas other patients will not. Unfortunately, current techniques cannot identify which pre-invasive lesions will lead to recurrent cancer.
New test identifies aggressive form of breast cancer
A University of Michigan researcher has invented a technology that can take some of the guesswork out of whether one form of early breast cancer is aggressive and likely to metastasize. Dr. Howard Petty, a cancer survivor himself, came up with an imaging technology called Biomarker Ratio Imaging Microscopy — or BRIM — that highlights certain proteins in aggressive cancer cells.
Could nanoparticles that mimic the NADPH oxidase be used to kill tumor cells?
Citation Posted online on June 27, 2016. (doi:10.2217/nnm-2016-0193) EditorialCould nanoparticles that mimic the NADPH oxidase be used to kill tumor cells?Howard R Petty*,1
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