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Abstract Background: Patient-centered care, which emphasizes clinical narrative competence of nurses, is receiving increasing attention. However, there is limited evidence indicating the level of clinical narrative competence of nurses. This study aimed to explore the current situation and associated factors of the clinical narrative competence of nurses in selected hospitals in Guangxi, China.
Abstract Background: Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) carries a poor prognosis. Although SBRT combined with cadonilimab and lenvatinib has shown encouraging antitumor activity in a prior prospective phase II trial, marked interpatient heterogeneity remains. Gut microbiota may influence antitumor immunity and could help identify patients more or less likely to benefit from this regimen.
Abstract Rationale and objectives: Bone metastasis (BM) is pivotal in prostate cancer (PCa) management. This study developed a multimodal model integrating MRI-derived deep features from the prostate gland (PG) and periprostatic adipose tissue (PPAT) with clinical variables for BM risk assessment. Methods: Retrospectively, 464 patients were recruited and randomly divided into training and internal test cohorts at a ratio of 7:3.
1 Introduction Immunosenescence represents a fundamental characteristic of the aging process, characterized by the gradual deterioration and dysregulation of the immune system, which constitutes a significant health risk for the elderly population. This phenomenon markedly increases vulnerability to infectious diseases, diminishes vaccine efficacy, and elevates the incidence of age-associated diseases (AADs) and malignancies (Liu et al. 2023; Lian et al. 2020).
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