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Abstract In non-small cell lung cancer (NSCLC), EGFR and HER2 mutations are generally considered mutually exclusive events, with a co-occurrence probability estimated to be less than 1%. Patients with either EGFR or HER2 mutations tend to exhibit low PD-L1 expression levels. The simultaneous presence of both EGFR and HER2 mutations accompanied by high PD-L1 expression is exceedingly rare.
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