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Abstract Background: The limited immune infiltration observed in pancreatic ductal adenocarcinoma (PDAC) is a major factor contributing to immunotherapy resistance and the consistently poor prognosis. Hence, identifying novel therapeutic targets and developing effective combination strategies to overcome immunotherapy resistance represent urgent and unmet clinical needs. Methods: The gene expression datasets and corresponding clinical information were collected from TCGA, GEO and ICGC.
Abstract Background: Lactobacillus/Bifidobacterium-associated host target genes curated in gutMGene v2.0 may reflect expression programs related to the immune microenvironment in hepatocellular carcinoma (HCC), but their significance in prognostic stratification and macrophage states remains unclear.
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